Nerve growth factor expression and perineural invasion in bile carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: Uemura Kenichiro 広島大学, 医歯薬保健学研究院(医), 講師 (60379873)
• Co-Investigator(Renkei-kenkyūsha): HIYAMA EISO 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胆管癌 / 神経周囲浸潤 / Nerve Growth Factor

Outline of Final Research Achievements

To investigate the impact of intratumoral nerve growth factor expression in resected extrahepatic cholangiocarcinoma on survival.Intratumoral nerve growth factor expression was investigated immunohistochemically in 112 patients with resected extrahepatic cholangiocarcinoma.High and low nerve growth factor expression was observed in 62 (55%) and 50 (45%) patients, respectively. For all 112 patients, no significant correlation was found between nerve growth factor expression and presence of perineural invasion (P = 0.942). Moreover, nerve growth factor expression was not associated with recurrence-free survival (P = 0.861) and overall survival (P = 0.973).
Intratumoral nerve growth factor expression is not associated with perineural invasion or recurrence-free and overall survival in patients with resected extrahepatic cholangiocarcinoma.

Free Research Field

肝胆膵外科