2016 Fiscal Year Final Research Report
Identification of PKM as a target for pancreatic cancer therapy
| Project/Area Number |
26462077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
Yamamoto Kuniharu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (00375073)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 膵癌 |
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| Outline of Final Research Achievements |
The aim of this study is to evaluate the role of PKM2 in the development of pacreatic cancer. We will identify PKM2 as a good target for anti-pancreatic cancer therapy. We analyzed the molecular mechanisms of PKM2 using pancreatic cancer tissue and pancreatic cancer cell lines. As a result, we demonstrated that PKM2 promotes panceratic cancer cell growth through Warburg effect.
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| Free Research Field |
消化器外科学
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