Development of a new expandable sheet for surgical correction of pediatric cardiac disorders by biodegradation and inducing tissue restoration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Osaka Medical College
• Principal Investigator: OZAWA HIDEKI 大阪医科大学, 医学部, 講師 (20277156)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Ryo 東京農工大学, 農学部, 准教授 (70334480)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心臓修復材料 / fibroin / 高分子ポリマー / エレクトロスピニング法

Outline of Final Research Achievements

The existing sheets widely used in pediatric cardiac surgery often need to be replaced as in reoperation because of degradation, calcification, and infection of the sheets. A new synthetic sheet was developed to solve the problems by optimizing mechanical property and biocompatibility. The sheet was made by electrospinning method using a mixture of silk fibroin (SF) and a synthetic polymer, thermoplastic polyurethane (TPU). Flexibility, water permeability, and suture retention strength of the SF/TPU sheet were excellent and equivalent to the existing sheets. When the SF/TPU sheet was implanted in the canine aorta, the intraluminal surface of the sheet was covered with restored tissue with no calcium deposition and modest inflammatory reaction. There was no sign of patch degradation in short time after the implantation. These favorable features and possible biodegradability of the SF portion warrant a long-term follow-up study.

Free Research Field

心臓血管外科