2016 Fiscal Year Final Research Report
Relationship between wall shear stress and angiogenesis, lymphangiogenesis in abdominal aortic aneurysm
| Project/Area Number |
26462105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 血管外科 / 腹部大動脈瘤 / MRI / ずり応力 / リンパ管 / 血管新生 / リンパ管新生 / 蛍光造影 |
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| Outline of Final Research Achievements |
Histological examination revealed chronic inflammation and angiogenesis / lymphangiogenesis in the intima and tunica media of the aortic aneurysm. Inflammatory cells, lymphangiogenesis, and lymphatic stasis were histologically observed in sites where lymphatic luminescence was remarkably evoked by ICG fluorescence imaging examination of the aortic wall. It was suggested that chronic inflammation and lymphangiogenesis are related to development and increase of aortic aneurysm.
The distribution of wall shear stress was not related to lymphangiogenesis or chronic inflammation.
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| Free Research Field |
血管外科
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