2016 Fiscal Year Final Research Report
Effect and molecular mechanism of Vasohibin on development of abdominal aortic aneurysm
| Project/Area Number |
26462106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Okayama University |
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Principal Investigator |
UCHIDA HARUHITO 岡山大学, 医歯薬学総合研究科, 准教授 (00550857)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 腹部大動脈瘤 / バソヒビン１ |
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| Outline of Final Research Achievements |
The role of Vasohibin-1 on development of Angiotensin II-inducced abdominal aortic aneurysm was examined. Angiotensin II of 1,000ng/kg/min was infused into male Vasohibin-1 +/- mice via osmotic mini-pump for 4 weeks, then abdominal aortic aneurysm was evaluated. Contrary to our expectation, hetero-knock out of Vasohibin-1 had minor effect on abdominal aortic aneurysm formation in comparison to control mice. In addition, no difference was observed between groups regarding several protease activities. This result implies that Vasohibin-1 plays little role on development of abdominal aortic aneurysm.
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| Free Research Field |
脈管学、大動脈瘤
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