2016 Fiscal Year Final Research Report
Integrated analysis followed by establishment of treatment strategy of Aortic aneurysm using genetic analysis and its derivatives.
| Project/Area Number |
26462114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 大動脈瘤 / 大動脈解離 / 遺伝子解析 / プロテオミクス解析 / 外科手術 |
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| Outline of Final Research Achievements |
① Basic research:MYH11 chosen as a possible gene for aneurysm formation in human being using human aneurysm tissue by genetic analysis. . Proteomics analysis of human aneurysmal tissue revealed MYH11 is a useful biomarker of aneurysm formation and a useful predictor of atherosclerosis in human being.
② Clinical research:We revealed characteristics of patients with acute type A dissection of the aorta, and showed recent progress of surgical outcome of acute type A dissection in Japan. Impact of re-entry at the brachiocephalic artery after surgical repair on its prognosis evaluated. Various improvement of diagnosis tools and surgical technique reported.
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| Free Research Field |
心臓血管外科
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