The identification of targeting molecules for EMT-activating signals from ErbB family receptor in lung cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: MENJU Toshi 京都大学, 医学研究科, 特定病院助教 (30527081)
• Research Collaborator: SABE Hisataka 北海道大学, 大学院・医学研究科・分子生物学教室, 教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺癌 / EMT / 浸潤転移 / Arf6 / GEP100 / EGFR / Grb2

Outline of Final Research Achievements

We revealed the enhancing mechanisms of Arf6 pathway via the binding between activated EGFR and GEP100. Grb2 overexpression induces the promotion of the binding of these molecules and its downstream molecule, Arf6 invasion pathway, leading the activation of EMT and in vitro invasive activity in lung cancer cells.
Furthermore, mutant Grb2 overexpression which does not bind EGFR did not show the enhancement of Arf6 pathway. These results possibly showed the inhibition of the binding among these molecular complex is the promising targets to suppress the invasive activity in lung cancer cells

Free Research Field

呼吸器外科