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2016 Fiscal Year Final Research Report

Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.

Research Project

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Project/Area Number 26462134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKeio University

Principal Investigator

Ohtsuka Takashi  慶應義塾大学, 医学部(信濃町), 准教授 (40306717)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords肺移植 / 拒絶反応 / メタロプロテアーゼ
Outline of Final Research Achievements

Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). We investigated inhibitor of Matrix metalloproteinases (MMPs) could ameliorate acute rejection in mouse trachea transplantation model. MMP inhibitor was given to the transplanted mice. The acute rejection of tracheal transplant was decreased in the allograft treated with MMP inhibitor. Regulatory T-cell infiltration and IL-10 mRNA expression increased in the allograft treated with MMP inhibitor. MMP inhibitor could be the treatment option for BO after lung transplantation.

Free Research Field

呼吸器外科学

URL: 

Published: 2018-03-22  

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