2016 Fiscal Year Final Research Report
Identification of biomarker for colorectal cancer metastasis to lung with CAGE analyses
| Project/Area Number |
26462136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | CAGE法 / 大腸癌 / 腫瘍マーカー / 肺転移 / 網羅的発現解析 / 次世代シークエンサー / 転移予測マーカー |
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| Outline of Final Research Achievements |
We conducted an exhaustive gene expression analysis in carcinoma tissue of colorectal cancer patients accompanied by metastases, using the cap analysis of gene expression (CAGE). There were differences in genes of which expression were promoted or suppressed between the cases with and without lung metastasis. Some gene expressions were enhanced only in cases with lung metastasis，specifically. The clinical application of genes identified in this work as a novel biomarker will enable us to detect earlier and to predict lung metastasis in colorectal cancer. It should help to promote clinical diagnosis and medical care of the cancer.
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| Free Research Field |
臨床系外科学
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