2016 Fiscal Year Final Research Report
Development of therapeutic strategy against invasive thymoma and thymic cancer targeting TrkB/BDNF signaling
| Project/Area Number |
26462146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 胸腺癌 / TrkB / BDNF / 増殖能 / 浸潤能 / 治療標的 |
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| Outline of Final Research Achievements |
In the analysis of TrkB expression using surgically resected specimen, only 1 case out of 48 cases was positive for TrkB in benign thymoma. However, all 5 cases were positive for TrkB in thymic cancer. It suggests that TrkB expression could be a diagnostic marker for thymic cancer. In the experiment using thymic cancer cell line, Ty-82, TrkB/BDNF signaling pathway contributed to proliferation and tumorigenesis. Therefore, TrkB/BDNF signaling pathway could be a new therapeutic target for thymic cancer.
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| Free Research Field |
臨床腫瘍学
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