2016 Fiscal Year Final Research Report
The role of epigenetics on preconditioning of neural stem cells
| Project/Area Number |
26462155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳虚血性障害 / 幹細胞移植 / エピジェネティクス / 耐性現象 |
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| Outline of Final Research Achievements |
Preconditioning with non-lethal stimuli is supposed to induce tolerance to the lethal insults in neural stem cells; however, the mechanisms underlying this phenomenon and the effects in stem cell therapy in stroke remain obscure. The results of this study revealed that hypoxic preconditioning to neural stem cells induced the protective effects to oxygen glucose deprivation and direct exposure to hemoglobin. In addition, hypoxic preconditioning in neural stem cells improved efficacy of stem cell therapy in a mice stroke model. Since the methylation of histone proteins was modified in the preconditioned neural stem cells, epigenetic mechanisms might be involved in hypoxic preconditioning.
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| Free Research Field |
脳神経外科
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