Possibility of a prevention or therapeutic drug for the cerebral vasospasm after subarachnoid hemorrhage

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Shinshu University
• Principal Investigator: MORO Makoto 信州大学, 医学部附属病院, 特任研究員 (90648651)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: くも膜下出血 / 脳血管攣縮 / β-アドレナリン受容体 / 血管弛緩

Outline of Final Research Achievements

We investigated the relaxant effects of β-adrenoceptor agonist on isolated rabbit basilar artery. As a result, β-adrenoceptor agonists including ritodrine hydrochloride dose-dependently relaxed on KCl-induced contraction of rabbit basilar artery.
Thereafter, we examined the messenger RNAs (mRNAs) expression of β-adorenoceptor on rabbit, dog and human basilar artery. The mRNA of β1 and β2-　adrenoceptor were detected on these basilar arteries .The in vivo pharmacological properties were tested, the effect of ritodrine hydrochloride on subarachnoid hemorrhage - induced cerebral vasospasm dog model. However, ritodrine hydrochloride did not improve this vasospasm.

Free Research Field

脳神経外科学