2016 Fiscal Year Final Research Report
Possibility of a prevention or therapeutic drug for the cerebral vasospasm after subarachnoid hemorrhage
Project/Area Number |
26462156
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Shinshu University |
Principal Investigator |
MORO Makoto 信州大学, 医学部附属病院, 特任研究員 (90648651)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | くも膜下出血 / 脳血管攣縮 / β-アドレナリン受容体 / 血管弛緩 |
Outline of Final Research Achievements |
We investigated the relaxant effects of β-adrenoceptor agonist on isolated rabbit basilar artery. As a result, β-adrenoceptor agonists including ritodrine hydrochloride dose-dependently relaxed on KCl-induced contraction of rabbit basilar artery. Thereafter, we examined the messenger RNAs (mRNAs) expression of β-adorenoceptor on rabbit, dog and human basilar artery. The mRNA of β1 and β2- adrenoceptor were detected on these basilar arteries .The in vivo pharmacological properties were tested, the effect of ritodrine hydrochloride on subarachnoid hemorrhage - induced cerebral vasospasm dog model. However, ritodrine hydrochloride did not improve this vasospasm.
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Free Research Field |
脳神経外科学
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