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2016 Fiscal Year Final Research Report

Examination of usefulness of miRNA as biomarker in brain trauma

Research Project

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Project/Area Number 26462160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKagawa University

Principal Investigator

Hatakeyama Tetsuhiro  香川大学, 医学部附属病院, 助教 (90602805)

Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsmicroRNA / MiR-451 / brain trauma
Outline of Final Research Achievements

We investigated that miRNA expression patterns and levels in plasma and cerebrospinal fluid are different from those of non-brain trauma patients and examined the possibility that their expression may be a prognostic factor or a biomarker. Plasma of head injured patients was measured with microRNA microarray, and as a result, there were three types with high absolute expression amount, miR-451, miR 223 and miR-16. Regarding the changes in microRNA in the cerebrospinal fluid, the expression levels of miR-451a, miR-21, and miR-16 were three types. MiR-451 was expressed most in all microRNAs. Further studies are needed to determine whether these microRNAs will become biomarkers of brain trauma from now on.

Free Research Field

脳神経外科

URL: 

Published: 2018-03-22  

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