2016 Fiscal Year Final Research Report
Elucidation of novel molecular mechanisms underlying the development of cerebral vasospasm after subarachnoid hemorrhage and searching for biomarkers of vasospasm
| Project/Area Number |
26462164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | くも膜下出血 / 脳血管攣縮 / 血管平滑筋収縮 / 血管リモデリング |
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| Outline of Final Research Achievements |
Cerebral vasospasm after subarachnoid hemorrhage (SAH) is characterized by delayed and prolonged contraction of cerebral arteries, which causes cerebral ischemia, thereby determining the prognosis of both life and neurologic function of SAH patients. The molecular mechanisms of cerebral vasospasm remain to be elucidated. In this study, we investigated the roles of several molecules including relaxin, TIMP-1 and MMP9, which were revealed to be upregulated in the rabbit basilar artery after SAH by microarray analysis, in increased vascular contractility after SAH. As a result, it is suggested that down-regulation of relaxin receptor expression and impaired TIMP-1/MMP9 balance contribute to acquiring persistency of vascular smooth muscle contraction and enhancement of vascular remodeling after SAH, respectively.
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| Free Research Field |
脳神経外科
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