Synergic effect of medical and stem cell therapy for stroke

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462165
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Nagasaki University
• Principal Investigator: HORIE Nobutaka 長崎大学, 病院(医学系), 助教 (70380912)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳梗塞 / 幹細胞 / 移植

Outline of Final Research Achievements

Intra-arterial cell transplantation provides timing-dependent cell distribution and post-stroke functional recovery via a combination of neuroprotection, reactive astrocyte enhancement and angiogenesis.At day 8 post-stroke, microglia activation was suppressed significantly, and interleukin (IL)-1β and IL-12p70 were reduced in both groups. Although high-dose MSCs were more widely distributed in the cortex and striatum of rats, the degree of intravascular cell aggregation and mortality was significantly higher in the high-dose group. Aging of hMSC may be a critical factor that affects cell therapy outcomes, and transplantation of young hMSC appears to provide better functional recovery through anti-inflammation effects, vessel maturation, and neurogenesis potentially due to the dominance of trophic factor secretion.

Free Research Field

脳卒中学