Cell therapy by human iPSC-transplantation for functional repair of stroke-damaged neural circuitry and malignant brain tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Keio University
• Principal Investigator: Mine Yutaka 慶應義塾大学, 医学部(信濃町), 訪問研究員 (10306730)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Kazunari 慶應義塾大学, 医学部, 教授 (70166940) ; OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: iPS細胞 / 脳梗塞 / 悪性脳腫瘍 / 再生医療 / 神経移植

Outline of Final Research Achievements

Cell therapy using iPS cells is attractive for regenerative medicine, cancer, etc., however, a lot of concerns such as rejection and tumor formation after transplantation remain at moment. To solve those issues, we have established the stable cell line of suicide gene-induced human iPSCs by modified method. When neural stem cells (NSCs) derived from suicide gene-induced human iPSCs were transplanted into mouse brain, those cells were alive and survived well, then wiped out by administration of drug. When those NSCs were transplanted into the brain of malignant brain tumor model animals, the tumor volume reduced and transplanted animals survived longer. Those findings suggested that our established human iPSC line might be useful as a therapeutic stem cells for both stroke and tumor.

Free Research Field

脳神経外科、神経移植