Development of new therapy for glioblastoma using stem cell differentiating agent

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462175
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Yamagata University (2015-2016); Tohoku University (2014)
• Principal Investigator: SONODA YUKIHIKO 山形大学, 大学院医学系研究科, 教授 (90302140)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 膠芽腫 / 腫瘍幹細胞 / CED

Outline of Final Research Achievements

We cultured glioma stem cell and added AICAR which acts differentiation of stem cells.
As results, differentiation of gliomas with minimal toxicity was observed. In vivo study, we injected AICAR into normal mice brain by CED methods. No severe toxicity was observed in mice brain. Finally we created mouse brain tumor model by implantation of glioma stem cell, then treated with AICAR by CED. Unfortunately, no survival benefit was observed in treated group compared with control group. In conclusion, AICAR was strong effect for differentiation of glioma stem cell, however inhibition of cell growth was modest.

Free Research Field

脳腫瘍