2016 Fiscal Year Final Research Report
Is LAT1 accociated with reguratory mechamnisms of stem-like cacer cell in high grade glioma?
| Project/Area Number |
26462176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUDA Kenichiro 山形大学, 医学部脳神経外科, 講師 (90536971)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | glioma / stem-like cacer cell / LAT1 |
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| Outline of Final Research Achievements |
We hypothesized that L-type amino acid transportor (LAT1), which is thought to be involved in the uptake of methionine, is involved in the maintenance mechanisms of glioma stem-like cells. Expressions of each of LAT1, SOX2 and HIF-1α in gliomas were analyzed by immunostaining. We compared World Health Organization grade 3/4 glioma, but no difference was seen in expressions of the three proteins. In addition, the LAT1-positive rate was low in all samples, at <5%, and no correlations were seen between methionine accumulation on positron emission tomography and expression of any of the three proteins. Based on these findings, LAT1 protein expression in glioma was considered low, and no results in support of the research hypothesis were obtained.
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| Free Research Field |
脳腫瘍
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