2016 Fiscal Year Final Research Report
Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade
| Project/Area Number |
26462178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 悪性グリオーマ / 浸潤 / 上皮間葉転換 / ＺＥＢ１／２ |
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| Outline of Final Research Achievements |
The invasiveness of glioma cells is the predominant clinical problem associated with this tumor type, and is well correlated with pathological malignant grade. In this study, we examined the expression of ZEB1 and ZEB2 with the goal of determining the role of ZEBs in glioma. ZEB1 and ZEB2 were highly expressed in all glioma cells used in this study. Double knockdown of both ZEB1 and ZEB2 suppressed tumor invasiveness more effectively than knockdown of either alone, in both in vitro and in vivo experiments. ZEB1 and ZEB2 were marginally expressed in grade II, but expressed at higher levels in grade IV. Levels of ZEB1 and ZEB2 are positively correlated with histopathological grade and invasiveness of glioma, suggesting that δEF1 family proteins (ZEB1 and ZEB2) would be useful as prognostic markers and therapeutic targets for glioma patients.
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| Free Research Field |
脳神経外科
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