2016 Fiscal Year Final Research Report
Functional role and contribution to angiogenesis of WT1 /ALCAM molecules in glioma stem cell
| Project/Area Number |
26462180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kyoto Prefectural University of Medicine (2015-2016)
Osaka University (2014) |
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Principal Investigator |
Hashimoto Naoya 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90315945)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ALCAM/sALCAM / WT1 / glioma stem cell / tumor formation / angiogenesis / tumor invasion |
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| Outline of Final Research Achievements |
Through a series of experimental procedure on ALCAM (Activated leukocyte cell adhesion molecule) and WT1 (Wilms’ Tumor 1) molecules using glioma stem cell and glioma cell, we found that WT1 plays an important role for tumor formation capability in those cells, and that both molecules are essential for tumor angiogenesis. Also, we revealed that sALCAM (soluble ALCAM) could relate to tumor-angiogenesis and tumor invasion ability.
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| Free Research Field |
脳腫瘍治療学
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