2016 Fiscal Year Final Research Report
Deep sequence analysis of treatment resistance in glioblastoma
| Project/Area Number |
26462186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIDE Takuichiro 熊本大学, 医学部附属病院, 診療講師 (40421820)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 膠芽腫 / ディープシークエンス / 治療抵抗性 / 再発 |
|---|
| Outline of Final Research Achievements |
To identify gene mutations on treatment resistance and recurrence, deep sequence analysis was done. Comparing to primary tumor, mutations were generally accumulate in recurrent tumor, however, some mutations were disappeared in recurrent tumors. These results suggested that recurrent tumors were not always same to primary tumors. This spatio-temporal heterogeneity is regarded as the cause of resistance for chemo-radiotherapy and recurrence of glioblastoma.
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| Free Research Field |
脳腫瘍
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