2016 Fiscal Year Final Research Report
Regulation mechanism of intracellular trafficking of somatostatin receptor
| Project/Area Number |
26462190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUTANI AKIKO 帝京平成大学, 健康メディカル学部, 講師 (80465252)
OSAMURA YOSHIYUKI 国際医療福祉大学, 大学院, 教授 (10100992)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 下垂体腺腫 / ソマトスタチン / 受容体 |
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| Outline of Final Research Achievements |
Somatostatin receptor and gsp mutation were analyzed in 56 examples of GH production pituitary adenoma. The adenoma that has plasma membrane expression of somatostatin receptor has significantly more responsive to somatostatin analogues. In 45 examples of pituitary adenomas, expression of somatostatin receptor 2A and 5 was analyzed. GH producing adenomas have expression of both receptors in all samples, and 2 ACTH producing adenomas have expression of somatostatin receptor 5.
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| Free Research Field |
下垂体腫瘍
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