Enhancement of the effect of photodynamic therapy for malignant brain tumors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical University
• Principal Investigator: Akimoto Jiro 東京医科大学, 医学部, 教授 (10212440)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 光線力学的療法 / 悪性脳腫瘍 / 光感受性物質 / 半導体レーザ / 治療効果増強

Outline of Final Research Achievements

We developed some experiments system in order to search for the enhancement of the effect of photodynamic therapy for malignant brain tumors using talaporfin sodium and semiconductor laser. In result, we found that PDT effect was enhanced by preloading an anticancer agent (temozolomide), and regulating the administrating dose of TS or the energy density of the laser beam. Furthermore, we found that PDT effect were demonstrated in malignant meningioma cell lines like as the malignant glioma cell lines. We would like to perform more detailed experiments and validation of these results of PDT for malignant brain tumors for improvement of the results of the existing PDT method in future.

Free Research Field

臨床医学