2016 Fiscal Year Final Research Report
Synthesis and evaluation of BSH-containing kojic acid (KA-BSH) as a novel agent for boron neutron capture therapy
| Project/Area Number |
26462192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
Kirihata Mitsunori 大阪府立大学, BNCT研究センター, 教授
Hattori Yoshihide 大阪府立大学, BNCT研究センター, 助教
Barth Rolf F. The Ohio State University, Pathology, Academy Professor
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 悪性神経膠腫 / 放射線治療 / ホウ素化合物 / 中性子捕捉療法 / コウジ酸 |
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) is a form of tumor-cell selective particle irradiation using low-energy neutron irradiation of nonradioactive boron-10 (10B) to produce high-energy alpha particles (10B [n, alpha] 7Li). To develop practical materials utilizing 10B carriers, we designed and synthesized novel dodecaboranethiol (BSH)-containing kojic acid (KA-BSH). In the present study, we evaluated the effects of this novel 10B carrier on cytotoxicity, 10B concentrations in F98 rat glioma cells, and micro-distribution of KA-BSH in vitro. Furthermore, biodistribution studies were performed in a rat brain tumor model. Based on these results, neutron irradiation was evaluated at the Kyoto University Research Reactor Institute with KA-BSH. Based on these findings, KA-BSH is a promising new B compound for BNCT of brain tumors.
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| Free Research Field |
脳神経外科学
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