2016 Fiscal Year Final Research Report
Development of equipment for next generation 5-ALA photodynamic diagnosis and treatment
| Project/Area Number |
26462194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
ISHIKAWA Toshihisa (60193281)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 光線力学診断 / 光線力学療法 / ５－アミノレブリン酸 / ポルフィリン / 手術ロボット / 悪性神経膠腫 / 脳腫瘍 |
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| Outline of Final Research Achievements |
The 5-ALA fluorescence guided excision method improves the resection rate of malignant glioma and improves the patient's prognosis. However, there are unresolved problems as a diagnostic method. For example, there are problems of false negatives due to lack of excitation light intensity, and ambiguity of diagnosis due to macroscopic subjective judgment. In order to overcome these drawbacks, development of a safe auxiliary light source and development of quantitative fluorescence diagnostic apparatus are desired.
In this study, we developed devices (ultrasound scalpel driven by fluorescence sensor, fluorescence sensor driven LED light source device for diagnosis, LED light source device for diagnosis) that overcome these drawbacks, and applied it clinically and verified its usefulness.
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| Free Research Field |
脳神経外科
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