2016 Fiscal Year Final Research Report
Amino Acid Pre-loading for Boron Neutron Capture Therapy
| Project/Area Number |
26462198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
SATO Eisuke 杏林大学, 保健学部, 助教 (00439150)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | BNCT |
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) can provide the delivery of tumor cell-selective high-linear energy transfer (LET) particle radiotherapy to tumor mass and the microscopic invasion while avoiding radiation damage to the surrounding normal brain tissue. The rationale of BNCT is based on the nuclear interaction of 10B with thermal neutrons with the release of high LET α and 7Li particles through the boron neutron capture reaction, 10B(n, α) 7Li. The very short path length (<9μm) of α-particles and 7Li enables high-LET irradiation of tumor cells without undesirable damage to 10B-unloaded normal cells.In this study,we assumed that neutral amino acid,would exhibit increasing effect of intracellular BPA level by co-loading.Neutron irradiation after Preloading of L-Phe-O-Et showed strongest cytocidal effect and L-tyr-O-Et also showed cytocidal effect.
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| Free Research Field |
脳神経外科学
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