Analysis of the mechanism of repetitive transcranial magnetic stimulation for chronic pain: fMRI analysis of rat model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Saitoh Youichi 大阪大学, 医学系研究科, 特任教授(常勤) (20252661)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: rTMS / 神経障害性疼痛 / 11.7T / 機能的結合

Outline of Final Research Achievements

Repetitive transcranial magnetic stimulation (rTMS) is expected to relieve intractable neuropathic pain. In this research, we made chronic pain model in rats with ligated sciatic nerve, and tried to analyze detailed image to investigate the pathophysiology of chronic pain and best stimulation parameter of rTMS. We prepared anesthesia equipment, rTMS machine and electromyogram. We successfully obtained anatomical image of rat brain in 11.7T MRI according to preceded anesthesia method and MRI parameters in 7T MRI. However, our 11.7T MRI needed placement of the animal in vertical position. We cannot obtain resting-state functional MRI of rat in stable anesthesia.

Free Research Field

脳神経外科