The anti-epileptic effect of spinal cord stimulation in kainic acid induced epilepsy rat model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: KONDO AKIHIKO 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (20721137)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: てんかん / 脊髄刺激

Outline of Final Research Achievements

Male Fischer 344 rats received SCS(spinal cord stimulation) with an epidural electrode at C1-2 level for one week. After SCS, the rats were injected with KA (12mg/kg, i.p.).The behavior was monitored for 6 h following KA injection and assigned a score for seizure stage using Racine scale. As a result, SCS with a frequency of 200Hz significantly reduced seizure severity in Kainic acid induced epilepsy rats model. The result suggests that SCS with high frequency exerts anticonvulsant effects.

Free Research Field

てんかん