2016 Fiscal Year Final Research Report
The anti-epileptic effect of spinal cord stimulation in kainic acid induced epilepsy rat model
Project/Area Number |
26462209
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders |
Principal Investigator |
KONDO AKIHIKO 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (20721137)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | てんかん / 脊髄刺激 |
Outline of Final Research Achievements |
Male Fischer 344 rats received SCS(spinal cord stimulation) with an epidural electrode at C1-2 level for one week. After SCS, the rats were injected with KA (12mg/kg, i.p.).The behavior was monitored for 6 h following KA injection and assigned a score for seizure stage using Racine scale. As a result, SCS with a frequency of 200Hz significantly reduced seizure severity in Kainic acid induced epilepsy rats model. The result suggests that SCS with high frequency exerts anticonvulsant effects.
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Free Research Field |
てんかん
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