A comparative study of resting state functional connectivity MRI and intracranial EEG for epilepsy surgery

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Nishibayashi Hiroki 和歌山県立医科大学, 医学部, 講師 (30372866)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: てんかん / 機能的MRI / 機能的結合 / 頭蓋内脳波 / 発作焦点

Outline of Final Research Achievements

Resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) were applied for pre-surgical evaluation of patients who underwent resective surgery via intracranial EEG. Reduced network centrality was prominent in ictal onset zones by voxel-to-voxel analysis. Sequential alteration of functional connectivity was analyzed by selecting remnant epileptic focus as a region of interest using seed-to voxel analysis. Imaging findings of rs-fcMRI altered according to clinic-encephalographic state. Rs-fcMRI is a useful tool even for an individual epileptic patient to explore epileptic focus and estimate clinical condition.

Free Research Field

てんかん、機能画像、機能的脳神経外科