2016 Fiscal Year Final Research Report
Inflammation and ischemia are Involved in the onset of epilepsy
| Project/Area Number |
26462217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | てんかん原性 / 慢性炎症 / 海馬 / パッチクランプ / 糖タンパク質 |
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| Outline of Final Research Achievements |
Inflammation of the brain has received widespread attention as an important factor in acquired epileptogenicity. Our clinical study suggested that expression of HMGB1 and TLR4 increases in epileptogenic lesion. HMGB1-TLR4 pathway also plays an important part in human epileptogenesis. It was discovered that in human epileptgenic hippocampus, HMGB1 acts chronically in localized areas and TLR4 becomes involved. On the other hand, leucine-rich alpha-2-glycoprotein （LRG1）therefore is implicated and expresses increasingly in a variety of physiological reactions, especially in inflammatory-related reactions. LRG gene [LRG1] was produced under a GFAP promoter in order to study the conditional overexpression of LRG in the brain. Electrophysiological characterization was used to analyze. The slopes of fEPSPs were significantly smaller in LRG-Tg mice than controls (p < 0.01), indicating an impairment of synaptic transmission in LRG-Tg mice.LRG may work on epileptic seizure deterrence.
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| Free Research Field |
脳神経外科学
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