Evaluation of physiological and pathological brain activities by simultaneous recording of single unit and intracranial EEG

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462221
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Jichi Medical University (2015-2016); Tokyo Health Care University (2014)
• Principal Investigator: Kawai Kensuke 自治医科大学, 医学部, 教授 (70260924)
• Co-Investigator(Renkei-kenkyūsha): MATSUO Takeshi 東京医療保健大学, 医学保健学部, 講師 (10733941)
• Research Collaborator: IBAYASHI Kenji 東京大学, 医学系研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 単一ニューロン記録 / 頭蓋内脳波 / 頭蓋内電極 / ブレインマシンインターフェース / てんかん

Outline of Final Research Achievements

The present study is the first attempt in Japan to analyze physiological and pathological brain activities using custom-made electrodes for simultaneous recording of intracranial EEG and single neuron firing. The study clarified some aspects of thus-far undetected brain activities and suggested possibilities that those recording promote the understanding of physiological and pathological neural processes. Furthermore, it was expected that those recording improve localization of epileptogenic zones and outcome of surgical treatment of epilepsy, improve the quality of functional mapping, and furhter help developing BMI for treatment of brain diseases and support for disabled as implantable neuromodulation therapy in future.

Free Research Field

脳神経外科、てんかん、てんかん外科