2016 Fiscal Year Final Research Report
Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.
| Project/Area Number |
26462226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | リハビリテーション / 理学療法 / 四肢機能再建学 |
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| Outline of Final Research Achievements |
Effect of hyaluronic acid (HA) for osteoarthritis is still controversial. We examined the histopathological changes and the friction coefficient in osteoarthritic knee joint after different molecular weight HA injection (low molecular weight HA, 0.8x106 Da or Ultra-high molecular weight, 6x106 Da) using a rabbit osteoarthritis model. Macroscopic findings showed that severe damaged cartilage was observed in 10% of Ultra-high molecular weight HA and 30% of low molecular weight HA and NS. The histological score and the friction coefficient value of Ultra-high molecular weight HA group were significantly lower than those of the control group (P < 0.05). Ultra-high molecular weight HA has potential chondroprotective effects and superior fiction coefficient. These factors would contribute to prevent progression of osteoarthritis. Intrajoint alteration of molecular weight HA should be clarified in future study.
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| Free Research Field |
医歯薬学
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