2016 Fiscal Year Final Research Report
In vivo regulation of chondroitin sulfate gene to recovery from spinal cord injury
| Project/Area Number |
26462232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMADA Yasushi 信州大学, 繊維学部, 教授 (70370666)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 再生治療 / 神経再生 / バイオマテリアル / 遺伝子治療 |
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| Outline of Final Research Achievements |
Injured adult neurons in the mammalian central nervous system (CNS) rarely regenerate, because some of the intracellular and cell-surface environmental factors inhibit axon regrowth. Chondroitin sulfate (CS) is the most abundant and potent exogenous inhibitor of axonal regeneration. CSGalNAcT1 is a key enzyme in CS biosynthesis. The sponge forms biomaterials impregnated with a mixture containing small molecule compounds or siRNAs was placed on the lesion area in mice suffered neural injuries. The recovery of these mice which treated with drug delivery systems reached the levels of satisfactory amelioration comparable to those of KO mice. Taken together, our results indicated that our drug and delivery system is a promising therapeutic target for treatment of the spinal cord injury and brain infarction, and many treatments of the neural damage.
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| Free Research Field |
分子細胞生物学・神経科学
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