2016 Fiscal Year Final Research Report
Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice
| Project/Area Number |
26462233
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
YOKOGAWA Noriaki 金沢大学, 医学系, 大学院生
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 放射線障害 / 硬膜外fibrosis / 硬膜損傷 / 髄液漏 |
|---|
| Outline of Final Research Achievements |
This study confirms that epidural fibrosis is induced in the late stages after high-dose irradiation in mice, and that overexpression of TGF-β1 occurs in a manner similar to radiation-induced fibrosis in other tissue. Additionally, thinning of the ABC was observed in the late stages after irradiation. Thus, consideration should be given to the possibility that these phenomena can occur as radiation-induced injuries of the spine.
|
| Free Research Field |
脊椎脊髄外科
|
