Analysis of the role and impact of glia limitans in spinal cord injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Yonezawa Tomoko 岡山大学, 医歯薬学総合研究科, 助教 (30304299)
• Co-Investigator(Kenkyū-buntansha): 斉藤 健司 新見公立短期大学, その他, 教授 (70270014)
• Co-Investigator(Renkei-kenkyūsha): OHTSUKA Aiji 岡山大学, 大学院医歯薬学総合研究科, 教授 (50168986)
• Research Collaborator: HOTTA Akira 岡山大学, 大学院医歯薬学総合研究科, 大学院生 ; TAKAGAKI Kazuya 岡山大学, 医学部保健学科 ; INOMOTO Saori 岡山大学, 医学部保健学科 ; SADO Yoshikazu 岡山大学, 医学部, 客員研究員 ; TAKIGAWA Tomoaki 岡山大学, 大学病院・整形外科学, 助教 ; Kadir Demircan Turgut Ozal University ; NINOMIYA Yoshifumi (元)岡山大学, 大学院医歯薬学総合研究科, 教授 (70126241)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 脊髄損傷 / 細胞外マトリックス / アストロサイト

Outline of Final Research Achievements

After spinal cord injury, glia limitans are destroyed. And then new glia limitans surround the injured tissue. We examined the temporal change of type IV collagen expression and the association between the type IV collagen expression and the secondary injury cascade using spinal cord injury mouse model. We found that the type IV collagen expression increased in injured cord and the temporal expression pattern was different depending on the alpha(IV) chain. The result suggested that the interaction between the extracellular matrix and cell play a role in injured spinal cord.

Free Research Field

分子生物学