Quantitative measurement of pain using functional magnetic resonance imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Oda Ryo 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80516469)
• Co-Investigator(Kenkyū-buntansha): 生駒 和也 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50516044) ; 藤原 浩芳 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (90381962)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: functional MRI / 磁気共鳴画像(MRI) / 末梢神経障害 / 慢性疼痛

Outline of Final Research Achievements

We investigated the course of rat brain nerve activation after the peripheral nerve injury by functional MRI. The results of functional MRI showed the activated regions were contracted 3 and 6 weeks after the injury. In contrast, a significant increase in blood flow was seen 9 weeks after the injury. In addition, the brain regions in which the blood flow increased were stained in immunohistochemical staining with c-Fos. The present study could detect the sequential change of the rat brain after peripheral nerve injury. The result was consistent with c-Fos staining.

Free Research Field

整形外科学