2017 Fiscal Year Final Research Report
Development of transcranial electrical stimulation for intraoperative neuromonitoring
| Project/Area Number |
26462248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
筒井 俊二 和歌山県立医科大学, 医学部, 講師 (70423960)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | spinal cord monitoring / transcranial stimulation / motor evoked potential / multi train stimulation / spine surgery |
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| Outline of Final Research Achievements |
Weinvestigated the safety of highfrequency MTS, behaviorally and histologically. TcMEPs were recorded from the triceps surae muscle in 38 rats. A multipulse stimulus was delivered repeatedly at different rates (2, 5, 10, 20, and 50 Hz), and was defined as MTS. A conditioned taste aversion method was used to investigate the effect of high-frequency MTS on learning and memory function. Subsequently, animals were sacrificed, and the brains were removed and examined using the standard hematoxylin-eosin method. Compared with conventional single train stimulation, TcMEP amplitudes increased 1.3, 2.1, 1.9, and 2.0 times on average with 5, 10, 20, and 50 Hz stimulation, respectively. The aversion index was[0.8 in all animals after they received 100 high-frequency MTSs. Histologically, no pathological changes were evident in the rat brains. High-frequency MTS shows potential to effectively enhance TcMEP responses, and to be used safely in transcranial brain stimulation.
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| Free Research Field |
整形外科
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