2016 Fiscal Year Final Research Report
Conditional deletion of hedgehog signaling attenuates intervertebral disc degeneration and osteophyte formation
| Project/Area Number |
26462254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SABANAI Ken 産業医科大学, 医学部, 助教 (70644863)
YAMANE Hirotoshi 産業医科大学, 医学部, 助教 (50721693)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨・軟骨代謝学 / 椎間板 / 骨棘 / 脊椎変性 / Hedgehog / Smoothened / Cre |
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| Outline of Final Research Achievements |
In this study, we investigate whether the deletion of smoothened (Smo), a key component of the hedgehog pathway in the process of endochondral ossification and intervertebral disc development, attenuates intervertebral disc degeneration and osteophyte formation in the mouse degenerative spine model. Control mice showed severe intervertebral disc degeneration, hypertrophic changes of chondrocytes in the vertebral end plate cartilage and osteophyte formation in the corner of vertebra, whereas, all these phenomena were impaired in the mice with conditional deficient of Smo, indicating that hedgehog signaling has a crucial role in the degenerative spondylosis of the spine.
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| Free Research Field |
整形外科学
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