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2016 Fiscal Year Final Research Report

Functional role of Syndecan-4 in the process of osteochondral repair

Research Project

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Project/Area Number 26462257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

ONODERA TOMOHORO  北海道大学, 大学病院, 講師 (70547174)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords整形外科 / 軟骨損傷 / 軟骨再生 / 骨軟骨修復 / 動物モデル
Outline of Final Research Achievements

We successfully developed novel osteochondral repair model by using young C57Bl/6 mice(Matsuoka M, Onodera T et al., Tissue Eng. 2015)。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice(Matsuoka M, Onodera T et al., Sci Rep. 2017)。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.

Free Research Field

整形外科

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Published: 2018-03-22  

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