Regulation of bone-associated cells differentiation and function by micro configuration of material surface

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: Myoui Akira 大阪大学, 医学部附属病院, 准教授 (10263261)
• Co-Investigator(Renkei-kenkyūsha): HAMAGUCHI Satoshi 大阪大学, 工学部, 教授 (60301826)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨分化 / バイオマテリアル / 微細加工技術

Outline of Final Research Achievements

Microfabrication technique using plasma etching make it possible to pattern pillar shape on the quartz and cocave/convex micro configuration on the polystyrene materials. It was revealed that the ability of a cell to proliferate was down regulated and bone formation was promoted on the microfabricated culture materials in the study using bone metabolism-associated cells like osteoblast and osteoclast. The number of osteoclast formation was altered according to the difference of scaffold materials. So it was indicated the possibility of controling the capability of bone metabolism associated cells by fabricating the adequate shape of cell attachment surface and using adequate materials.

Free Research Field

整形外科