Development of non-operative treatment for local control and new bone formation against metastatic bone tumors

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MURATA Hiroaki 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (90360031)
• Co-Investigator(Kenkyū-buntansha): 小藤 和孝 明治国際医療大学, 医学教育研究センター, 准教授 (50649340) ; 芦原 英司 京都薬科大学, 薬学部, 教授 (70275197)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ビスホスホネート / 転移性骨腫瘍 / 骨肉腫 / 軟部肉腫

Outline of Final Research Achievements

Bisphosphonates (BPs) show anti-tumor effects against many malignant tumors. However, for clinical applications, a novel approach is needed to maintain a high concentration of BP for prolonged tumor exposure.　Hydroxyapatite (HA) and bone cement are used in orthopedic surgery as a sustained-release system for drugs.　Therefore, the present study assessed the effects of BPs-loaded HA and bone cement in metastatic sites of malignant tumor cells in vitro and in vivo.　The antitumor effects of BPs -loaded HA were less potent compared with those of BPs -loaded bone cement in several malignant tumor cell lines. Moreover, BPs -loaded bone cement also exerted antitumor effects against pulmonary metastases and primary lesions, without exhibiting systemic toxicity in vivo.

Free Research Field

医歯薬学