2016 Fiscal Year Final Research Report
Character of platelet rich fibrin and effect for meniscal healing
| Project/Area Number |
26462275
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ORITA Kumi (荻 久美) 大阪市立大学, 大学院医学研究科, 博士研究員 (40748597)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 半月板再生 / フィブリン / 単核球 |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to assess how to produce the Platelet Rich Fibrin (PRF) and characteristics and effectiveness for meniscal healing. PRF from rat and human was stably produced using medifuge and rapid aspiration. As measured by ELISA, levels of VEGF, IGF-1, TGF-b, bFGF, and SDF-1 were abundantly included in PRF derived from human peripheral blood. For healing model of rat meniscus, repaired tissue in PRF group was similar to control group and there seemed to be no effect to accelerate the meniscal healing. While, repaired tissue in bone marrow blood (BM) group had metachromasia in Immunostaining. This indicated that BM might be more suitable material for meniscal healing than PRF.
|
| Free Research Field |
半月板再生、スポーツ整形外科
|
