2016 Fiscal Year Final Research Report
Analysis of circulating tumor cells using telomerase-specific adenovirus in patients with sarcoma and metastatic breast cancer
| Project/Area Number |
26462280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Aichi Medical University (2015-2016)
Department of Clinical Research, National Hospital Organization Kure Medical Center (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 末梢血循環癌細胞 / 肉腫 / 乳癌 / 肺転移 / 骨転移 / テロメラーゼ |
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| Outline of Final Research Achievements |
We attempted to detect viable circulating tumor cells (CTCs) in peripheral blood from sarcoma and bony metastatic breast cancer patients using a telomerase-specific viral agent. The number of CTCs postoperatively was significantly higher in sarcoma patients with metastasis than in those without metastasis (p = 0.022). The number of postoperative CTCs was significantly higher in dead sarcoma patients than in living patients (p = 0.014). A significant relationship was found between the number of CTCs and both occurrence of lung metastasis and prognosis in patients with sarcoma. Detection of CTCs using this method may be useful for prognostic evaluation of sarcoma patients. CTCs were detected in one patient who showed resistance for chemotherapy and hormone therapy in bony metastatic breast cancer patient. The number of CTCs may correlate with sensitivity to chemotherapy or hormone therapy in metastatic breast cancer patients.
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| Free Research Field |
骨軟部腫瘍
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