2016 Fiscal Year Final Research Report
Molecular mechanisms of osteoarthritis regulation by Tace signaling
| Project/Area Number |
26462285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INUI Hiroshi 東京大学, 医学部附属病院, 講師 (60583119)
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 琢 東京大学, 医学部附属病院, 講師 (30456107)
篠田 裕介 東京大学, 医学部附属病院, 講師 (80456110)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 整形外科学 / 関節病学 |
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| Outline of Final Research Achievements |
TNF-alpha converting enzyme (Tace), also known as a disintegrin and metallopeptidase domain 17 （Adam17), is a transmembrane enzyme which regulates various signaling pathways. Here, we have investigated how Tace regulates osteoarthritis development. Cell culture experiments and mouse experiments have revealed that Tace exerts catabolic effects on chondrocytes or cartilage.
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| Free Research Field |
整形外科学
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