Development of new therapy for hemophilic arthropathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462286
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Hirose Jun 東京大学, 医学部附属病院, 講師 (00456112)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 血友病性関節症 / 血友病 / モデルマウス

Outline of Final Research Achievements

We made a hemophilic arthropathy model by inducing knee internal hemorrhage to hemophilia B model mice and analyzed them. We confirmed that joint destruction progressed with a time course by micro CT and histology. It was confirmed that TNFalpha, IL-1beta and IL-6 which were inflammatory cytokines increased by performing immunostaining. These results suggest that the increase of inflammatory cytokines is a potential cause of inflammation in hemophilic arthropathy. Osteoclasts were present in the synovium of the punctured knee and it was found that synovial cells expressed RANKL which is the factor indispensable for osteoclasts differentiation.

Free Research Field

整形外科学