Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462287
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Jinno Tetsuya 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (90343152)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 変形性膝関節症 / 動物モデル / 卵巣摘除 / トレッドミル / 滑膜炎症 / 関節軟骨

Outline of Final Research Achievements

Although osteoarthritis (OA) is a multifactorial disease, little is reported regarding the cooperative interaction between these factors on cartilage metabolism. Here we examined the synergistic effect of ovariectomy (OVX) and excessive mechanical stress (forced running) on articular cartilage homeostasis in a mouse model resembling a human post menopause condition. Histological analysis revealed that OVX or forced running respectively had subtle effect on cartilage degeneration. However, the combination of OVX and forced running synergistically enhanced synovitis and articular cartilage degeneration. Interestingly, these results were observed specifically in Balb/c mice, since we did not observe any synergistic effects of OVX and forced running on articular cartilage degeneration in C57Bl/6J mice.
Since surgical procedure was not performed on the knee joint directly in this model, this model is useful in addressing the molecular pathogenesis of naturally occurring OA.

Free Research Field

整形外科学