Therapeutic effect of CD271 + BMSc and hyaluronic acid injection for the animal model of spontaneous osteoarthritis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Fukui
• Principal Investigator: Miyazaki Tsuyoshi 福井大学, 学術研究院医学系部門(附属病院部), 講師 (80324169)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 変形性膝関節症 / 軟骨再生

Outline of Final Research Achievements

At 5 weeks post transplantation, partial cartilage repair was noted in the HA-MSC group but not in the other groups. Examination of CFDA-SE-labeled cells demonstrated migration, differentiation, and proliferation of MSC in the HA-MSC group. There was strong immunostaining for type II collagen around both residual chondrocytes and transplanted MSCs in the OA cartilage.
This scaffold-free and technically undemanding technique appears to result in the regeneration of articular cartilage in the spontaneous OA animal model. Although further examination of the long-term effects of transplantation is necessary, the findings suggest that intra-articular injection of HA-MSC mixture is potentially beneficial for OA.

Free Research Field

整形外科学領域