New Implant Coating Technology with Phosphopullulan Bioadhesive Materials

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Kagawa Yohei 岡山大学, 医学部, 客員研究員 (90584962)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: リン酸化プルラン / インプラントコーティング

Outline of Final Research Achievements

In the orthopaedic surgery, the early fixation due to the new bone formations around the implant is important. Hydroxyapatite (HA) is often coated on the cementless implant surface. A variety of coating methods have been used, but the best coating procedure still remains controversial. A purpose of this study is to get promotion of the new bone formations by coating HA on implants with phosphopullulan (PP) as matrix. In the mechanical examination, in the quantitative elemental analysis, and in the histological examination, there was evidence of bone neoformation on the surface of the implants in PP+HA groups than in any other groups.
The PP has little harm to the living body, and does not remain in the body as an alien substance to be absorbed in vivo. The PP coating had a beneficial effect on interfacial shear strength and peri-implant new bone formation in rabbit femurs during the early stages of bone healings.

Free Research Field

生体材料