Long-term survival of total joint arthroplasty by drug inhibition of autophagy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462306
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kagoshima University
• Principal Investigator: Komiya Setsuro 鹿児島大学, 医歯学域医学系, 教授 (30178371)
• Research Collaborator: SAITOH YOSHINOBU
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 人工関節ルーズニング / オートファジー / 感染

Outline of Final Research Achievements

Polyethylene particle promoted the expression of inflammatory cytokines in macrophage cell lines. But inhibition of cytokine signals could not inhibit the autophagy. Aseptic and septic loosening prevent the long term survival of total joint arthroplasty. We evaluated the accumulation of polymorphonuclear leukocytes (PMNs) in periprosthetic tissues during second-stage revision surgery. There was no statistical relationship between PMNs-positivity and relapse of infection. Intraoperative evaluation of PMNs during second-stage revision surgery promote overdiagnosis of persistent infection. We retrospectively reviewed 18 patients with bipolar hip hemiarthroplasty (BHA) that necessitated revision. Pathological findings showed that several patients with early BHA migration were PMNs-positive, which was indicative of infection. Our findings suggest that some portion of rapid BHA prosthesis migration is caused by mild infection.

Free Research Field

人工関節