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2016 Fiscal Year Final Research Report

Pathological role of mitochondrial oxidative stress in cartilage degeneration

Research Project

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Project/Area Number 26462319
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionJuntendo University

Principal Investigator

Nojiri Hidetoshi  順天堂大学, 医学部, 准教授 (10317456)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords酸化ストレス / 軟骨 / 変形性関節症 / 加齢 / 変性 / メカニカルストレス
Outline of Final Research Achievements

We herein demonstrate that mechanical loading promoted mitochondrial superoxide generation and selective Sod2 downregulation in chondrocytes in vivo and that mitochondrial superoxide inducer also downregulated Sod2 expression in chondrocytes in vitro. A genetically manipulated model revealed that Sod2 deficiency in chondrocytes also resulted in mitochondrial superoxide overproduction and dysfunction, thus leading to cartilage degeneration. Intra-articular injection of a permeable antioxidant effectively suppressed the mechanical loading-induced mitochondrial superoxide generation and cartilage degeneration in mice. Our findings demonstrate that mitochondrial superoxide plays a pivotal role in the development and progression of osteoarthritis, and the mitochondrial superoxide balance may therefore be a promising target for the treatment of cartilage degeneration.

Free Research Field

整形外科

URL: 

Published: 2018-03-22  

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